Pathologic Characterization of a Murine Model of Human Enterovirus 71 Encephalomyelitis
نویسندگان
چکیده
منابع مشابه
Pathologic characterization of a murine model of human enterovirus 71 encephalomyelitis.
We describe a model of Enterovirus 71 encephalomyelitis in 2-week-old mice that shares many features with the human central nervous system (CNS) disease. Mice were infected via oral and parenteral routes with a murine-adapted virus strain originally from a fatal human case. The mice succumbed to infection after 2 to 5 days. Vacuolated and normal-appearing CNS neurons showed viral RNA and antige...
متن کاملRecombinant Human Enterovirus 71
Hand, foot and mouth disease (HFMD) is a common illness of infants and young children <10 years of age. It is characterized by fever, ulcers in the oral cavity, and rashes with blisters that appear on the palm and sole. The most common causal agents of HFMD are coxsackievirus A16 (CV-A16) and human enterovirus 71 (HEV71), but other enteroviruses, including CV-A5 and CV-A10, can also cause it. W...
متن کاملimpact of human enterovirus 71 genotypes in meningoencephalitis in iran
conclusions the c genotype should be considered as the prevalent ev71 circulating genotype in iran, particularly in cases of aseptic meningitis. patients and methods viral rna was extracted from 170 cerebrospinal fluid samples obtained from children aged under 8 years with a primary diagnosis of aseptic meningitis. specific ev71 pcr was conducted to identify the genotype of the detected ev71 vi...
متن کاملSeroepidemiology of Human Enterovirus 71, Singapore
Human enterovirus 71 has caused outbreaks in many parts of the world, especially Southeast Asia, with some fatal cases. The epidemiology of this viral infection is not well understood. We conducted a serologic survey in Singapore children, and the results indicate that infection occurs largely in preschool settings.
متن کاملCrystal structure of human enterovirus 71.
Enterovirus 71 is a picornavirus associated with fatal neurological illness in infants and young children. Here, we report the crystal structure of enterovirus 71 and show that, unlike in other enteroviruses, the "pocket factor," a small molecule that stabilizes the virus, is partly exposed on the floor of the "canyon." Thus, the structure of antiviral compounds may require a hydrophilic head g...
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ژورنال
عنوان ژورنال: Journal of Neuropathology & Experimental Neurology
سال: 2008
ISSN: 0022-3069,1554-6578
DOI: 10.1097/nen.0b013e31817713e7